The pi-SEE-HSelMQC method completely suppresses lipid and water with potential clinical applications in disease diagnosis and therapeutic interventions. Detection of lactate with a hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner: Application to tumors and muscle ischemia. In vivo one-dimensional pi-SEE-HSelMQC CSI images of lactate and choline, acquired from the MDA-MB-231 human breast cancer xenograft in a nude mouse, as well as two-dimensional pi-SEE-HSelMQC imaging of lactate and choline acquired from the PC3 human prostate cancer xenograft in a nude mouse, also had opposite image offsets, shifted away from the spurious residual water signals in the image center. ![]() The lactate and choline images from a yogurt phantom displayed opposite image offsets without image overlapping. This study presents the use of a selective homonuclear multiple quantum coherence transfer sequence (SelMQC-CSI), at 1.5 T, to better quantify lactate in the presence of lipids. He Q Shungu DC van Zijl PC Bhujwalla ZM Glickson JD J Magn Reson B 1995 Mar 106(3):203-11. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate resonances. The choline-selective and lactate CH-selective RF pulses were phase incremented by 10° in opposite signs, synchronized with the phase-encoding steps. Single-scan in vivo lactate editing with complete lipid and water suppression by selective multiple-quantum-coherence transfer (Sel-MQC) with application to tumors. On a Bruker 9.4T MRI spectrometer, the pi-SEE-HSelMQC sequence was implemented. The selective multiple quantum coherence (Sel-MQC) sequence is a magnetic resonance spectroscopy (MRS) technique used to detect lactate and suppress co-resonant lipid signals in vivo. ![]() ![]() Abstract: Phase-incrementing MRSI (pi-MRSI) method has resolved overlapping biomarker images in the presence of a read-gradient. Thisstudy presents the use of a selective homonuclear multiple quantum coherence transfer sequence (SelMQC-CSI), at1. Coherence pathway analysis of J-coupled lipids and lactate and effective suppression of lipids upon the selective multiple quantum coherence lactate editing.
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